Has anyone heard of DNA methylation clinical trials?

I'm always looking for the food/herbal substitutes of synthetic drugs if those drugs are not available to everyone.....in this case 5-aza (decitabine).....FDA approved for types of leukemia and MDS.

Since methylation leads to HNF4a loss, the target is to demethylate or curtail the methylation process so retention or promotion of HNF4a is supported therefore suppressing pancreatic cancer growth. Here's what I found:

HNF4a (Hepatocyte Nuclear Factor 4 alpha) is a transcription factor that plays a crucial role in regulating gene expression in the liver and other tissues. It is involved in various metabolic processes, including glucose and lipid metabolism.

Demethylation refers to the removal of a methyl group from a molecule, which can affect gene expression and is a key process in epigenetics. Certain foods and herbs are known to influence demethylation and overall epigenetic regulation.

Foods and Herbs That May Influence Demethylation:
Green Tea: Contains epigallocatechin gallate (EGCG), which has been shown to have demethylating effects1.
Turmeric: Curcumin, the active compound in turmeric, has been studied for its potential to influence DNA methylation2.
Garlic: Contains compounds like allicin that may have epigenetic effects3.
Cruciferous Vegetables: Such as broccoli, cauliflower, and Brussels sprouts, contain sulforaphane, which may influence DNA methylation.
Berries: Rich in antioxidants and compounds that may affect epigenetic mechanisms.

Herbs with Anti-Inflammatory Properties:
Turmeric: Known for its anti-inflammatory and antioxidant properties2.
Ginger: Contains gingerol, which has anti-inflammatory effects.
Chamomile: Has anti-inflammatory and calming properties.
Holy Basil: Known for its adaptogenic and anti-inflammatory effects.
Ashwagandha: An adaptogen that helps reduce inflammation and stress.
These foods and herbs can be incorporated into your diet to potentially support healthy gene expression and reduce inflammation.

I would add Berberine and Boswellia to the list. Most if not all found on Amazon.....look for organic if possible and in nano-particle form or liquid if available for optimal results.

Boswellia inhibits pancreatic cancer.....https://onlinelibrary.wiley.com/doi/10.1002/ijc.25966

@mnewland99

I searched clinical trials for DNA methylation and there are many for different types of cancer.

To search for clinical trials I suggest following site from National Cancer Institute.
https://www.cancer.gov/research/participate/clinical-trials-search
Another source to search is government's site for Clinical Trails
https://clinicaltrials.gov/
The best source of information may be asking your provider.
Have you asked your oncologist about possible clinical trials?

That is my next step / asking about clinical trials; I just feel like a get a lot of negative feedback from them about what I consider innovative therapies. Seems like this demethylation is still in the research stages but seems very promising once researchers figure out to change these molecular processes in humans.

There is a free clinical trial search service provided by the Pancreatic Cancer Action Network (#PanCAN.org). PanCAN has the largest clinical trial database specific to pancreatic cancers. A case manager can run a trial search based on your case history by calling 877.272.6226,M-F, 7:00am-5:00pm PT.

Unfortunately, this is heard too often from pancreatic cancer patients. Many oncologists are just not knowledgeable or have a strong interest in clinical trials. Perhaps it is a bandwidth issue. But there are a few. Once you have narrowed trials for which you are eligible, you must then apply. And then hopefully find a physician that is knowledgeable enough to advise you . Sometimes, digging on the internet can turn up research and current data on the trials in progress. With small drug companies you can d sometimes find the reports they provide on investor calls .