I have IgA kappa light chain MGUS (8 years). My kappa/lambda ratios have gradually been creeping up (13) , but not at biopsy stage yet. Meds can have cascade effects on health so I just try to manage mine through diet, exercise, and the usual stuff doctors yammer about. I do take 1 gm of bioavailable curcumin 2x/day, just to see if that has any effect on suppressing the kappa curve (not all lab rats are rats). Various brands, mine is Qunol. Absorption rates of curcumin from turmeric are miniscule, so modifying the curcumin by adding a lipid (fat) to it for better GI absorption may help. Supplements aren't regulated by the FDA, unfortunately. https://pubmed.ncbi.nlm.nih.gov/27025786/ One can search for peer-reviewed papers using "curcumin TNF" , or MGUS. TNF is tumor necrosis factor