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What is the recommended treatment after 6 Pluvicto doses?

Posted by donalan @donalan, Mar 13, 2023

I will have had 6 Pluvicto doses next month. PSA has decreased some. SE have been much easier to tolerate than chemotherapy. What is the recommended maintenance treatment after receiving Pluvicto?

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melcanada | @melcanada | Jul 10 8:51am

On radium 223 or Xofigio 6th shot USA at Peace bridge customs picked me out at car booth and sent me over to office where a gigger counter was aimed at me and results sent to scientist in NYC to attest I had medical Radium 223 only Carry your cards folks

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melcanada | @melcanada | Jul 11 9:14am
In reply to @rxharleydude "I am currently on Xofigo. Getting ready to get my fourth dose out of six. Won’t..." + (show)
@rxharleydude

I am currently on Xofigo. Getting ready to get my fourth dose out of six. Won’t really know how effective it is until after the sixth dose and a PMSA scan. Unlike Pluvicto, you don’t have to have had chemo to get Xofigo, so for me Pluvicto would be a potential next step in treatment. But, I would have to have tried a round of chemo first. Most, if not all of my cancer is in the bones and Xofigo focuses only on bone cancer. Pluvicto, on the other hand is reputed to be affective on cancer in the organs and lymph nodes as well.
I really appreciate reading about the experiences and comments of everyone in this group and would like to put a plug in to everyone to include frequent prayer to our God in heaven, giving him thanks for all the good things that happen and asking for his help to cope with the problems.
May God bless and heal us all!

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Did 6 injection Xofigo feel great diarrhea some days getting CT as we speak tomorrow bone scan

Precious blood of Jesus heal me daily

What is next psa 31.4

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1 reply
Moderator
Colleen Young, Connect Director | @colleenyoung | Jul 15 2:21pm
In reply to @larke "After a significant delay - 4 months- I will resume Pluvicto, with careful monitoring of side..." + (show)
@larke

After a significant delay - 4 months- I will resume Pluvicto, with careful monitoring of side effects and PSA. Can find no related data.

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@larke, what led to your having to delay treatment with Pluvicto? How are you doing?

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1 reply
larke | @larke | Jul 15 3:49pm
In reply to @colleenyoung "@larke, what led to your having to delay treatment with Pluvicto? How are you doing?" + (show)
@colleenyoung

@larke, what led to your having to delay treatment with Pluvicto? How are you doing?

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No initial delay. Completed the usual 6 treatments, six weeks apart. Relative success: PSA 75 to 8. March 13 completed.
Agreed to be a test case for MORE Pluvicto and will likely begin in early August. Likely two or three applications.
Larke

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4 replies
lag | @lag | Jul 15 4:45pm
In reply to @larke "No initial delay. Completed the usual 6 treatments, six weeks apart. Relative success: PSA 75 to..." + (show)
@larke

No initial delay. Completed the usual 6 treatments, six weeks apart. Relative success: PSA 75 to 8. March 13 completed.
Agreed to be a test case for MORE Pluvicto and will likely begin in early August. Likely two or three applications.
Larke

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larke, I am happy to hear that there are clinical trials for men who could benefit for more than six Pluvicto infusions. My husband is already worrying about what comes after his sixth infusion in August.

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2 replies
larke | @larke | Jul 15 4:58pm
In reply to @lag "larke, I am happy to hear that there are clinical trials for men who could benefit..." + (show)
@lag

larke, I am happy to hear that there are clinical trials for men who could benefit for more than six Pluvicto infusions. My husband is already worrying about what comes after his sixth infusion in August.

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This is somewhat on the experimental side. IF good reaction (much lower PSA) and still functional, UPennMedicine is trying this. Seems logical. Delay from March ‘til now for me to recover from cumulative effects of radiation.
I’m 85.
Luck .

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smc24 | @smc24 | Aug 10 9:18pm
In reply to @gaherrma "Wanting to know what doctors are telling patients about what is course of action after first..." + (show)
@gaherrma

Wanting to know what doctors are telling patients about what is course of action after first six pluvicto treatments?

Can Pluvicto be repeated?
Has it been in EU where it was approved longer ago?

Gina

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Did anyone every answer the question, can Pluvicto can be repeated after the initial 6 treatments? Quesses and opinions don't count.

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1 reply
melcanada | @melcanada | Aug 11 5:47am
In reply to @melcanada "Did 6 injection Xofigo feel great diarrhea some days getting CT as we speak tomorrow bone..." + (show)
@melcanada

Did 6 injection Xofigo feel great diarrhea some days getting CT as we speak tomorrow bone scan

Precious blood of Jesus heal me daily

What is next psa 31.4

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PSA now 41 1 Looking at chemo Mets still in bones only T 5 L! S! and 9th left rib

help

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rxharleydude | @rxharleydude | Aug 12 11:19pm
In reply to @larke "No initial delay. Completed the usual 6 treatments, six weeks apart. Relative success: PSA 75 to..." + (show)
@larke

No initial delay. Completed the usual 6 treatments, six weeks apart. Relative success: PSA 75 to 8. March 13 completed.
Agreed to be a test case for MORE Pluvicto and will likely begin in early August. Likely two or three applications.
Larke

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Can you tell me who is heading up the “extra Pluvicto dose” study? I am currently on Pluvicto and will be facing the same issue of “where do we go next” when I finish the six dose regimen. It would be great for my medical team to follow the results of that study!

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smc24 | @smc24 | Aug 15 12:03pm
In reply to @larke "No initial delay. Completed the usual 6 treatments, six weeks apart. Relative success: PSA 75 to..." + (show)
@larke

No initial delay. Completed the usual 6 treatments, six weeks apart. Relative success: PSA 75 to 8. March 13 completed.
Agreed to be a test case for MORE Pluvicto and will likely begin in early August. Likely two or three applications.
Larke

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Large, where are you receiving the 2nd round of Pluvicto treatments?

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