The answer, I think, is that it varies widely from person to person.

I'm on a fairly high dose of HU (ten 500 mg capsules / week). Other than scaring myself silly about taking the first capsule, I haven't had any side effects at all.

From postings here, I learned to never take HU on an empty stomach, and that drinking plenty of water during the day is beneficial.

This is the perfect place for your questions and concerns -- someone here will have good advice for you!

I started a little over a year ago w/500 mg/day 6 days/week. I have hot flashes again 😬 but they are few and far between (I’m 72 and thought I was done w/that—but guess not). I also have a strange itching sensation at my elbow / upper forearm. I use rubbing alcohol to reduce the itch and sometimes an itch cream….but the alcohol actually works best. Sometimes I’ll get a headache…and I’m not sure any of these are drug related — but easy to blame!