My RA journey began in 1995. I have had fairly good success with treatments but have dealt with chronic pain and physical changes for nearly 30 years. I started treatment with Prednisone and Vioxx. I feel fortunate that I was newly diagnosed when Enbrel (one of the first biologica) was approved for RA treatment. Vioxx was great but it was discontinued and I have been taking Celebrex since then. Enbrel worked initially but became ineffective quickly. I was then prescribed Remicade (my wonder drug) and Methotrexate which I took for 7 years successfully. I only stopped to try to get pregnant. I was unable to conceive after 2 1/2 years of trying with fertility treatments so went back to Remicade but unfortunately it wasn’t as effective. I then tried Rituxan and was pretty well controlled with this medication and methotrexate for 15 years. In 2023 I was infected with Covid two weeks after my dosing and developed Covid pneumonia and had severe illness that required hospitalization and 24/7 oxygen therapy for months. I was treated with high doses of steroid which helped control my RA but not the pneumonia. A pulmonologist prescribed Cellcept which helped control the RA and treated the pneumonia. I now have interstitial lung disease. I have low IgG level possibly caused by Rituxan and maybe why my Covid was so severe . I opted not to go back on Rituxan because of this and the fact that the drug’s effect lasts for six months. I opted for a medication with shorter effects so I can stop it if I become ill in the future. I will be starting Simponi very soon. If anyone has experience with this medication I’d like to hear about it.