← Return to Prolia treatment for osteoporosis: What is your experience?

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@windyshores

If you stop Prolia, there is no choice at this point in time, other than Reclast (the strongest) or alendronate. Prolia has a rebound and you can lose bone density and have increased fracture risk very quickly, according to my doctors, Dr. Ben Leder's YouTube video "Combinations and Sequencing", McCormick's book "Great Bones" and many other sources (just citing my favorites). Reclast or alendronate are needed after every other osteoporosis medicine, actually, to "lock in" gains, but it is especially important after Prolia due to the strong rebound. Maybe you could do a bisphosphonate for one year (one Reclast for instance)-????

It may be as simple as one Reclast infusion but I don't know how long you need bisphosphonates to counter the rebound. McCormick and some doctors will use the CRX bone marker test to monitor when the bisphosphonate is needed, exactly (timing of infusion for instance) and also how you are doing with the rebound risk. For instance if you did one Reclast, the CTX could be done to make sure it is working and then the CTX could be done months later, and continue as a monitoring approach evaluating whether more bisphosphonate is needed. But there may be a standard answer to this already. It's just that you might want to do less alendronate or Reclast because of prior use.

I don't know if there is any research into other sequences after Prolia but I have not seen any. Always ask your doctor! Generally bisphosphonates are taken 3-5 years.. Prolia is also an anti-resorptive. So you have only been on anti-resorptive. I think a situation like yours is complex and needs medical advice. Do you have a good endocrinologist?

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Replies to "If you stop Prolia, there is no choice at this point in time, other than Reclast..."

I took forteo for two years then alendronate for 5. Now on my 11th shots of evenity and my endocrinologist wants me on prolia. Thanks