@mayblin , I confused you with someone else with this reply meant for you: Regarding my A1c response to Berberine, I have little doubt the Berberine reduced it from 5.6 to 5.2, however, I have kept it below 6 with a low carb, mediterranean type diet, and Alpha Lipoic Acid supplement, also known to lower glucose levels, for several years after prediabetic diagnosis. I take other supplements which likely help as well, but there was a dramatic drop again after Berberine when I had changed nothing else during 6 months of taking it prior to testing A1c. The fact that my LDL and triglycerides also took a significant drop pointed strongly to the Berberine.