My mutations are KMT2C and ASXL1, they were detected in a past bone marrow biopsy.
the ASXL1 didn't even show up in the NGS. the genes that were impacted are as follows
TERF2 VAF = 60.7%
FAT1. VAF= 51.1%
AKAP6 VAF= 47.9%
ATM VAF= 37.9%
DUSP22 VAF=22.4%
KMT2C VAF= 2.5%
I believe the only ones they seem to be concerned about are the KMT2C wich was at 3.4%
and the ASXL1 at 1.35%
To me this is all Mumbo Jumbo.
My counts have fluctuated for the past 25-30 years. I started out having a couple of lymph
nodes biopsied and my 1st BMB was in 1999 when my white count was at somewhere below
3.0.
On the lighter side i never really get sick or ill. I did have a rather large pulmonary embolism in 2017 and another BMB a year later. had another BMB in 2023, and my last one a couple of weeks ago. ( I think I'll start charging for bone marrow). The Mayo clinic is wonderful.
Perhaps they will find a cure to stabilize those wacko blood counts. I'd hope for a pill. My Dr
at the Mayo Clinic did mention that these mutations may clear on their own . Who knows.
we can only hope . I believe miracles happen to everyone every day.
So to everyone with this wacky diagnosis heads up.