Hi Gloria, Welcome to Connect! It’s very encouraging that you’re having success with your treatments for Multiple Myeloma. I’m sorry to hear you’re having swelling after the Dexamethasone infusions. That is one of the potential side effects of Dexa. It’s a good idea if you can, to take frequent walks during the day and then elevate your feet over your heart for 20 minutes or so, every couple of hours. (Lie on a sofa with your feet up on the back, for example) That can help reduce swelling your feet are puffy. Is this primarily in your feet and ankles or your hands too?