Well, you know, that all should be discussed with the doctor. I don't know that what I do will relate to your issues.

I am on 2.0 lpm

I use it all night long. And sometimes during the day...Oh, maybe 1 - 2 hours per daytime, max.

And then, at night, all sleeping hours.

I have heard more advanced discussion of oxygen therapy, generally.

That, for example, there are very professional masks that give you a much better edge with the oxygen.

And other things that I don't do. Those discussions go back over 10 years, I don't know that I remember them all that well. That was back with Yahoo Groups. All those closed down.

The Environmental Health Center in Dallas does very advanced work with patients that have chemical injury (I had carbon monoxide poisoning).

They might be able to answer a few questions? Not sure:
https://www.ehcd.com/
++++

Then there is the American Academy of Environmental Medicine:
https://www.aaemonline.org/
++++

And the Clymer Clinic:

through Dr. Neville
https://drandrewneville.com/
++++

Now all of those places include treatments that are somewhat controversial. But, you know, there might be people there who could answer some of your questions.

I mean, I am pretty sure all of them have MDs and RNs...

so perhaps they can answer some deeper questions for you.