10mg is a lot of melatonin. The body's natural production of melatonin is the equivalent of about 1mg or less. I started taking 2mg a night to compensate for loss of melatonin caused by a beta blocker. The pharmacist said to expect it to take a month or so to start working. I had to be patient, but he was right.

My doctor said to make sure to separate the small evening dose of prednisone and the melatonin by at least two hours. I was able to reduce the dose to 1mg after a few months, but am currently taking 2mg again since a flare and prednisone increase. I sleep well on that. Will reduce down to 1mg again when I'm able.