I was on Velcade for 4 cycles, with Rev. 14 days on/7 days off. And DeX 40 mg/week. I had terrible neuropathy in hands and feet, the 1st week, and a rash to lower legs and feet, and some high fever for like three days, in the evenings. The 2nd week, my Hematologist held the Velcade, and continued it again on the 3rd week, at the same dose, so I was told. Had less neuropathy, no rash, and no more fevers from it. Was told, my body went into shock during induction. I recieved it in very slow sub Q injections, once a week. The injection sites would be red, then turn brown, and scaly, then resolve.