Why shouldn't I take Prolia?

guinivere,
Prolia has been considered the drug of last resort because it is difficult to stop it safely. So if you figure on abbreviated longevity, you could take it the rest of your life.
It's the drug of last resort because Prolia works by stopping osteoclasts from fully developing. While it is working those preosteoclasts collect in great numbers. When you stop Prolia they all finish developing and destroy your bones, unless you take another antiresorptive to stop the osteoclasts. This was unknown when Prolia was first approved and the first patients provided us with a lesson by having what are called cascade fractures in the spinal vertebra, because the compress one after the other.
Many of the doctors prescribing during the early "experimental" period will never prescribe Prolia again.
Now, usually, patients are warned not to even be late for the next injection. Plans are made for which antiresorptive to follow Prolia.
It has to be an antiresorptive because we are just fighting what medical literature describes as a pool or resevoir of osteoclasts.
Prolia and the bisphosphonates are antiresorptives. The bone they build is weaker bone with avascular networks of unsupplied nerves that cannot repair themselves. They embody a risk for osteonecrosis of the jaw and atypical femur fracture.
Anabolic medications are thought to be a better start. To begin with vascularized bone, strong bone before following with and antiresporptive.
Bless your choice.

@gently
Thanks your comments. Please share the source for this information. Thanks

@24faith,
was there any particular part of the post that you wanted documented. I always try o answer the full question first. There are myriad sources and would like to answer thoroughly. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124202/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718877/ https://personalinjurylawcal.com/dangerous-drugs-lawyer/prolia-lawsuit/ https://www.fda.gov/drugs/drug-safety-and-availability/fda-adds-boxed-warning-increased-risk-severe-hypocalcemia-patients-advanced-chronic-kidney-disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427054/

Thanks for the literature review. Appreciate your time.

I had been told Prolia and Fosamaz were similar. True?

@zeniada
They are similar because they are both antiresorptive. They both stop osteoclasts from breaking down bone. The way they do that is quite different. While it is thought that both drugs slow the maturation of osteoclasts Fosamax has the advantage of the bisphosphonate cladding the bone for years following treatment. Prolia is much stronger at preventing the development of osteoclasts. It is really effective. The problem is that when you stop Prolia all those undeveloped osteoclasts develop. If a patient misses a treatment or ends treatment with Prolia those osteoclasts dissolve the bone. So after Prolia a person has to take something to control those osteoblasts Usually a bisphosphonate.

Or else simply staying on it forever. Which is my plan at age 86.

Yes I agree

I’m new to the osteoporosis treatment systems. Have had the diagnosis for 6+ years but treatment started 18 months ago. I had a very disagreeable reaction to the 2nd dose of Fosamax so put off trying Residronate. Took tis one for 7 weeks before the breathing problems started. I also experienced every side effect listed. Very uncomfortable. Now my doctor has moved so I’m waiting for insurance approval of a new doc. I was told the next drug would be an injection. I am assuming it will be Prolia. Other than another allergic reaction, is there a reason I would want to stop Prolia ?

I’m 78 years old have osteopenia and a couple of bone fractures over the last few years. I’ve been on Proia for two years now no side effects. Will have a bone density test next month hopefully seeing improvement.