I am 10 months post liver transplant and within the last 2 months I have started experiencing the same conditions. ""Especially in my hands"". I can barely open a twist off jar anymore and it wasn't an issue before a couple months ago. I started to look into it and there are a couple possibilities. (info from my Ins carrier support team) First and foremost, I was told that the Fluconazol (Diflucan) can have an overpowering interaction with the Tacrolimus. It was suggested to talk with the Doctor and maybe decrease the amount of Fluconazol I take daily. They said that the Fluconazol can decrease the effectiveness of the Tacrolimus allowing several possible side effects to be more pronounced. Right now I'm on 200mg Fluconazole in the morning and 1mg Tactrillimus in the morning and .5mg Tacrolimus in the evening. Secondly, I was told to check and then keep track of the manufacturer of the medications I'm taking. Apparently, some drug stores will give you the same drug although they might switch it out with a different manufacturer. I was told you can ask the drug store to check into that and confirm. I haven't looked into either yet as I just got this information yesterday. But I do plan to look into both.