PMR & Statins
Recently, I’ve been trying to research out the possible connection of PMR and the use of statin drugs. Does anyone have any information they would like to share regarding this subject matter. Apparently there is now some concern that statins “might” cause PMR however, it is hard to sort out what is PMR pain and what is the muscular weakness/pain caused by the statins. I have been on statins, most recently Crestor, for a total of 20 years. I decided to take a statin “vacation”10 days ago. I recently had my cholesterol checked…. my results were all within range.
In November 2023 I was diagnosed with giant cell arteritis (GCA) & polymyalgia. I am told that both of these often go hand-in-hand. I was put on 60 mg of prednisone to control the inflammation in my head. (42 days of headaches). Once the GCA was under control and polymyalgia pain was diminished. I was able to start a prednisone taper per my rheumatologist. April of 2024 I was down to 3 mg. The month of May I dropped down to 2 mg when I hit the wall and the polymyalgia returned. In June. I upped my prednisone to 3 mg. With “minimal” pain relief. I have experienced many side effects while on the prednisone. Currently I have taken myself off of the statins and the prednisone to see if I can manage my pain. I have also been following an anti-inflammatory diet for several months and I am now trying to add in some physical therapy exercises geared to help with PMR. I have been off prednisone for almost a week and I do not see that much of a difference in the pain level from 3 mg to zero. We shall see what happens.
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You possibly need to consider that your high dosage of steroids did have a side effect of depressing your adrenal grands long term. This can cause systemic pain when titrating down off the prednisone that could be confused with PMR pain. Waking up your adrenal glands is a major portion of the steroid triturating process. If they do not wake properly you could have what is known as adrenal insufficiency. This can be identified/eliminated via blood tests. This test must be drawn at the proper time of day, it is a sensitive test, but properly done it will reveal if there is an adrenal problem. Talk with your PCP or Endochronogist about eliminating this as a contributing cause for the steroid titrating pain.
Here is a short Mayo Clinic article on Adrenal Insufficiency https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-q-and-a-understanding-adrenal-insufficiency/
Thank you so very much for bringing this to my attention. I’m going to keep a close watch on this possibility of adrenal insufficiency. I have a rheumatologist, as well as an endocrinologist that I can consult with.
My PMR started about two weeks after starting statins.
I have been taking Atorvastatin for almost 30 years. My first thought when I was experiencing pain in glutes and shoulders that is was being caused by the statin. I stopped taking statin but it made no difference. My PMR started about 10 days after getting my 4th covid vaccine. No way to know if they are related but it's been a damn long year.
Good Luck!
Phil