Vitamin B complexes.
I take a vit B complex capsule everyday for my PN. Lately I learned that some of the vitamins are not in their most bioavailable form, for example B1 thiamine should be Benfotiamine and B12 must be methylcobalim. Has any one sussed this problem out.
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Not sure this will suss it out for you but the references may help. I myself stay away from B complex vitamins due to the B6 content which can make neuropathy worse. The following information is extracted from the Why the Protocol document in the FAQs from the Protocol website that I have been using since 2016. Here's the link to the FAQs on the website - https://theprotocolworks.com/faq/.
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B1 Thiamine 50 mg - Altogether, vitamin B1 (thiamine) plays a pivotal role in the process of nerve regeneration: in nerve cells, it facilitates the usage of carbohydrates for energy production and protects them against oxidative stress, resulting in normalized pain sensation and reduced hyperexcitability.
B2 Riboflavin 50 mg - A 2017 review indicates that supplementing with B vitamins has the potential to promote nerve repair. This may be because B2 can speed up nerve tissue regeneration and improve nerve function. B vitamins may also be useful in relieving pain and inflammation.
B3 Niacin 20 mg - Among the B vitamins, niacin has long been recognized as a key mediator of neuronal development and survival, and may be of value for the treatment of neuropathy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737454/
Biotin 20000 mcg - Biotin can be considered as a potential therapeutic for the treatment of neuropathic pain, and supplementation with this vitamin could reduce the required doses of analgesic drugs. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216157/
B Vitamin discussion: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294980/.
Methylfolate 400 mcg - methylfolate is the active form of folic acid. The administration of l-methylfolate has been associated with increased levels of nitric oxide, thereby increasing blood flow to the peripheral nerve tissue.
https://www.hmpgloballearningnetwork.com/site/podiatry/blogged/why-you-should-consider-use-supplements-management-diabetic-neuropathy.
Methylcobalamin B12 4000 mcg - Methylcobalamin helps in the synthesis of neuronal lipids, regeneration of axonal nerves and has neuroprotective activity, which promote neurons to function in proper way and thus improves Alzheimer disease, Parkinsonism, Dementia and neuropathic syndromes. It is an approved treatment for peripheral neuropathy.
https://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v3-id1076.php.
Solgar has a sub-lingual methylcobalamin 1000mcg.
I intend to ask my neurologist about this info. Thanks for posting. I have a follow up appointment in a couple of weeks. I hesitate to take anything without checking with him.
With my B12 diagnosis, I am very interested in nerve regeneration. Didn’t think it was possible. I just found a case study, that offered me a lot of hope.
Do you take these every day at the doses you have shown.
Thanks for that John,it’s a lot to take in and I don’t know whether my body or pocket could take it.
Thanks for that John. That’s a lot of info to take in and also quite frightening. I don’t think I could sustain such a complicated regime nor could I afford it. I’m worried my condition is just going to get worse. My GP basically told me to go away and learn to live with it.
Hi Celia , I will be very interested in what your neurologist has to say. Unfortunately I am not under a neurologist just the GP.
Yes, have been taking them since 2016 but a few have changed during this time.
I take B12 under the tongue. B12 is not metabolized well from the stomach route.
maybe a pharmacist has the information you are seeking.