Talk to your doctor before the infusion. My first infuse was a nightmare....wound up in the hospital for pain management. Second infusion I talked to doctor ahead of time. He started me on pain meds before the infusion. I requested a 45 min. Infusion instead of the 15 min the time before. It made all the difference. Of course you still need to drink lots of water and take Tylenol in preparation for the infusion. Wishing you all the best ...