Has anyone been on gem/cis/durvalumab (Imfinzi) and when it stopped working gone to another chemo that worked and if so what was the new chemo treatment?
I was on gem/cis/durvalumab (Imfinzi) and stable, transitioned to durvalumab (Imfinzi) for maintenance. Tumor markers CEA and CA19-9 have been increasing dramatically. PET scan scheduled for August 18th. Expect it will show that the two small tumors are more active or if we have additional reoccurrence.
Trying to get ready for doctor meeting after PET scan.
My oncologist wants me to start on gem/cis/durvalumab because 2 of my lymph nodes are getting bigger.How long were you on the gem/cis and did it work?I am reluctant to do the treatment , do you think it s worth it.Any reply will be appreciated
@waflanders, it is so hard to hear when a treatment regimen stops working. I'm tagging fellow gallbladder cancer members like @steve90154@pgf@formayor@alie@heartofgold57@viopp to rejoin the discussion and add their suggestions as you prepare for the upcoming PET scan and appointment to discussion next options.
My oncologist wants me to start on gem/cis/durvalumab because 2 of my lymph nodes are getting bigger.How long were you on the gem/cis and did it work?I am reluctant to do the treatment , do you think it s worth it.Any reply will be appreciated
@johnny2053, I'm tagging @waflanders to make sure they saw your question. I believe @alie@edie78t@lovingwifeterry also had treatment with gemcitabine and cisplatin plus durvalumab and may be able to share their experiences.
Johnny, did you decide to go ahead with treatment? How are you doing?
@johnny2053, I'm tagging @waflanders to make sure they saw your question. I believe @alie@edie78t@lovingwifeterry also had treatment with gemcitabine and cisplatin plus durvalumab and may be able to share their experiences.
Johnny, did you decide to go ahead with treatment? How are you doing?
I have been on this regimen since June 29, 2023. I am on a 3-week cycle, chemo on the first day of the first 2 weeks and off the 3rd week. I only get the Imfinzi once on that cycle. I had a scan after 4 cycles and the size of the tumor was "relatively unchanged". However, the good news is that I have been able to manage the side effects well which includes (for me), nausea feeling, fatigue, loss of appetite and constipation.
You can manage the side effects by reading up and by trial and error to see what works and what does not. If your tumor is growing, you should not wait! Hope this helps.
@johnny2053, I'm tagging @waflanders to make sure they saw your question. I believe @alie@edie78t@lovingwifeterry also had treatment with gemcitabine and cisplatin plus durvalumab and may be able to share their experiences.
Johnny, did you decide to go ahead with treatment? How are you doing?
Diagnosed with stage 4 gallbladder cancer.
I have my first appointment with the oncologist at Mayo.
I’m having a hard time finding support.
Is anyone still here?
Diagnosed with stage 4 gallbladder cancer.
I have my first appointment with the oncologist at Mayo.
I’m having a hard time finding support.
Is anyone still here?
Welcome to Mayo Connect, I hope you find it helpful and supportive.
I am sure your full of questions and anxiety. Many members have beem in same situation your in.
Welcome to Mayo Connect, I hope you find it helpful and supportive.
I am sure your full of questions and anxiety. Many members have beem in same situation your in.
I’m traveling to Rochester location from rural Alaska. I’ve been there twice already - once for labs/scans & early this week for biopsy.
I was unprepared for the stage 4 diagnosis. My care in Alaska & waiting for Mayo to have availability has wasted precious time. Now the realization that this is not curable is sinking in.
I’m 56 with 8 beautiful kids - four still at home. I don’t need to say more. I know we all know how devastating this cancer is.
I’m just looking for support.
I’m traveling to Rochester location from rural Alaska. I’ve been there twice already - once for labs/scans & early this week for biopsy.
I was unprepared for the stage 4 diagnosis. My care in Alaska & waiting for Mayo to have availability has wasted precious time. Now the realization that this is not curable is sinking in.
I’m 56 with 8 beautiful kids - four still at home. I don’t need to say more. I know we all know how devastating this cancer is.
I’m just looking for support.
@tammie4jc
I hope your adult children are some support.
I live in Rochester, but am only in town part of summer. Other times in northern MN cabin. If anything I can do to help or just someone to talk to, let me know. I am cancer survivor, but never in same situation you are in.
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My oncologist wants me to start on gem/cis/durvalumab because 2 of my lymph nodes are getting bigger.How long were you on the gem/cis and did it work?I am reluctant to do the treatment , do you think it s worth it.Any reply will be appreciated
No changes to my wife. We have not returned for any more CT scans. All is good for my wife.
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2 Reactions@johnny2053, I'm tagging @waflanders to make sure they saw your question. I believe @alie @edie78t @lovingwifeterry also had treatment with gemcitabine and cisplatin plus durvalumab and may be able to share their experiences.
Johnny, did you decide to go ahead with treatment? How are you doing?
I have been on this regimen since June 29, 2023. I am on a 3-week cycle, chemo on the first day of the first 2 weeks and off the 3rd week. I only get the Imfinzi once on that cycle. I had a scan after 4 cycles and the size of the tumor was "relatively unchanged". However, the good news is that I have been able to manage the side effects well which includes (for me), nausea feeling, fatigue, loss of appetite and constipation.
You can manage the side effects by reading up and by trial and error to see what works and what does not. If your tumor is growing, you should not wait! Hope this helps.
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2 ReactionsNot yet my cancer is very slow going and my oncologist said to wait , We also send my cancer and blood for molecular screening
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2 ReactionsCan someone comment if they had inflammation of spleen when diagnosed?
Diagnosed with stage 4 gallbladder cancer.
I have my first appointment with the oncologist at Mayo.
I’m having a hard time finding support.
Is anyone still here?
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Helpful -
Hug
1 Reaction@tammie4jc
Welcome to Mayo Connect, I hope you find it helpful and supportive.
I am sure your full of questions and anxiety. Many members have beem in same situation your in.
You may want to check out this discussion, "Anyone diagnosed with Gallbladder cancer?"
https://connect.mayoclinic.org/discussion/gallbladder-cancer/
On Connect you can read comments from oldest to newest, or sort from newest to oldest.
Which Mayo location are you going to? Do you have to travel far?
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3 ReactionsI’m traveling to Rochester location from rural Alaska. I’ve been there twice already - once for labs/scans & early this week for biopsy.
I was unprepared for the stage 4 diagnosis. My care in Alaska & waiting for Mayo to have availability has wasted precious time. Now the realization that this is not curable is sinking in.
I’m 56 with 8 beautiful kids - four still at home. I don’t need to say more. I know we all know how devastating this cancer is.
I’m just looking for support.
-
Like -
Helpful -
Hug
1 Reaction@tammie4jc
I hope your adult children are some support.
I live in Rochester, but am only in town part of summer. Other times in northern MN cabin. If anything I can do to help or just someone to talk to, let me know. I am cancer survivor, but never in same situation you are in.
Have you told your family?
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Helpful -
Hug
2 Reactions