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MCRC with peritoneal Mets. Is Immunotherapy an option?
I have MCRC that has metastasized to the peritoneum. It has BRAFv600e mutation and is MS-Stable. I had a partial and then a full colectomy. 2 rounds of chemo and now taking Encorafenib and Panitumumab which reduced my CEA from 178 to 5. My CEA is now rising so it appears I am developing resistance to the meds. My cancer does not show up with scans and is non-resectable.
I just saw a paper from SWOG S2107 that indicates that immunotherapy may be effective after the administration of my current meds. It apparently turns MS-Stable look like MS-High and is a "primer" for immunotherapy.
My Oncologist stated that I won't qualify for a clinical trial because my cancer is not measurable.
Does anyone have a suggestion, or can you direct me to a program that may accept me? With my mutation there are no new meds that are effective.
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I would like to thank you for all the information you have provided. It is very pertinent and helpful, especially the March 2024 abstract which I had not seen before. You seem to be well educated in this area and I really appreciate your comments. I am a retired detective and for decades I conducted investigations for other people and now I am doing it for myself and sharing with others in my situation. Last year, I met with Dr Deperalta from Northwell, and I was put on the PIPAC waitlist. They called me in January, but I delayed it because my treatment was working well but they kept me on the list. I just had a dx lap and have been accepted and I am awaiting my first treatment.
After researching immunotherapy, I believe that it is the future and studies continually show it is safe and very effective and with Dr Morris and others researching MSS and BRAF the future is looking pretty exciting.
Thank you again for your input
God Bless,
Tim