My blood disorder was initially diagnosed as essential thrombocythemia but was later changed to myelofibrosis. My hematologist/oncologist prescribed Jakifi about 6 months ago. I have CBC lab draws every three months to track results ... so far the drug is helping. I continue to experience bruising and occasional bleeding from bruises but it's manageable. Before Jakifi, I was experiencing dizziness, headaches, low energy, weight loss and critical high platelet counts. While the drug is working, as mentioned by others, it's very expensive. I'm on Medicare and have a part D stand-alone Rx plan, but I'm still on the hook for $3,000 monthly co-pays. I've been successful in obtaining financial assistance through the PAN Foundation. With the passage of the Inflation Reduction Act of 2022, caps for out-of-pocket costs were put in place for Medicare patients with a Part D plan. For 2024 the cap is $8,000 which I've already reached. In 2025, the cap is $2,000 for name-brand (not generic) drugs. A generic for Jakafi will not be available until the patent expires in December 2028 ... do your own research. Good luck to all and God bless