Hi, thanks for the invitation to join this support group. Side effects from pazopanib have been minimal since moving to the lowest dose (primarily extreme bouts of diarrhea) three years ago. Radiation treatment side effects have caused neuropathy in my right leg beginning in the toes now up to mid thigh which has caused weakness in the muscles and my balance is off. Consequently I have trouble with stairs, hilly terrain, and walking in general. I am told that exercise is key which is not a problem for me, I am an active person and always enjoyed various forms of exercise on a consistent basis (less intense now for obvious reasons). My PT guy suggested acupuncture, I am on my 7th weekly visit and plan to continue for a while (not covered by insurance unfortunately). It is a slow process and it might not disappear, but I willing to try anything to get back to where I was before the neuropathy set in.