← Return to MCRC with peritoneal Mets. Is Immunotherapy an option?

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@roywalton

You're certainly at one of the finest institutions. Suggest you ask for tumor informed CTDNA test results to monitor therapy going forward. Don't pay attention to CEA. Ask your oncologist to review with you.....March 2024 Abstract re BRAF MSS....JCR Abstract 5056: Molecular characterization of microsatellite stable (MSS) colorectal cancer (CRC) patients with a BRAF V600E mutation. More...Recent studies have found that the multi‐pathway regimens combined with PD‐1/PD‐L1 inhibitors can enhance the efficacy of anti‐PD‐1/PD‐L1 in MSS CRC by increasing the number of CD8+ T cells, upregulating PD‐L1 expression and improving the tumour microenvironment. This paper reviews the research progress of PD‐1/PD‐L1 inhibitors in combination with cytotoxic T‐lymphocyte–associated antigen 4 (CTLA‐4) inhibitors, oncolytic virus, intestinal flora, antiangiogenic agents, chemotherapy, radiotherapy and epigenetic drugs for the treatment of pMMR‐MSI‐L/MSS CRC.

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Replies to "You're certainly at one of the finest institutions. Suggest you ask for tumor informed CTDNA test..."

Thanks for the info, I forgot to mention that 3 separate CtDNA tests and 3 CT/PET scans were negative so the only indicator of active disease was CEA. Dr Van Morris seems to be a leader in this area of immunotherapy in MSS CRC and I have been in contact with him but for now I believe the PIPAC trial is my best course. I will stay on top of the immunotherapy trials.