1. < Osteoporosis & Bone Health

What happens after Tymlos?

Posted by alknapp @alknapp, Feb 21 4:55pm

I’m going to be finishing the 18 month course of Tymlos in April/May of this year. Endo is saying that I should follow that with Prolia (within weeks) and then Reclast.

Has anyone else followed that treatment plan or have any comments about it?

Thank you.

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windyshores | @windyshores | Jun 18 3:29pm
In reply to @jomck "He claims it is the best drug on the market to hold the gains I made..." + (show)
@jomck

He claims it is the best drug on the market to hold the gains I made with Tymlos. He is a Rheumatologist who was highly recommended. Good idea about the 2nd opinion, tho.

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@jomck many of us do Reclast (or Fosamax) after an anabolic. Prolia may help but when you stop it, you will do Reclast then!

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loriesco | @loriesco | Jun 19 11:43am
In reply to @dooshie "@gravity3 Hi there. My cardiologist is very confident with HRT replacement after finishing up my Tymlos...." + (show)
@dooshie

@gravity3 Hi there. My cardiologist is very confident with HRT replacement after finishing up my Tymlos. My rheumatologist wants me to begin Reclast infusion, so I’m researching and weighing my risks and benefits from both. I know I need HRT for my girlie parts for sure because I have suffered for years with vaginal atrophy so that will be a plus. But I would like the least amount of medication to maintain the gains I’ve had with Tymlos. I will have another Dexa scan next month and will see if the additional months on this med made a difference. I had a Dexa in Nov after being on Tymlos for 18 months but my doc approved for me to continue to the 24th month. Hoping there will be more gains.
I know it will take a couple of months for me to notice a difference with the HRT so I’m hoping I will feel the difference in my sleep, energy, sex, moods, etc. My doc says I will. Have a great weekend!

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All of my "aging" problems occured after stopping HRT. I did Bio-Identical HRT for 8 or 10 years. I did it topically (rubbing it into the skin.) It worked GREAT for me. For all the "girlie" problems - to maintain skin, muscles and bones. Hormones keep us youthful. However, I had to balance cancer risks with estrogen products so the bioidenticals were the answer - to be compounded in the proportions I needed. The first year was finding the right combo of estrogen, progesterone, and testosterone in the right amounts. I was very pleased. It was a bit of a struggle to get it all in place. But I used so little every day that it wasn't expensive (I had to pay out of pocket). Kept EVERYTHING in the right balance. I highly recommend it!

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bluebonnet242 | @bluebonnet242 | Jun 23 10:40am
In reply to @windyshores "@dooshie just to be clear, while my Reclast dose will be lower, it will also be..." + (show)
@windyshores

@dooshie just to be clear, while my Reclast dose will be lower, it will also be more frequent. Much depends on how I react (my first infusion is this week) and the doctor leaves the dose and timing up to me, as long as it meets his guidelines for effectiveness. He gives me parameters and I appreciate both his guidance and his caution. I have afib and kidney disease so the suggestion of lower dose came from the doctor.

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How did your reclast infusion go? I hope it went well!

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1 reply
windyshores | @windyshores | Jun 23 9:02pm
In reply to @bluebonnet242 "How did your reclast infusion go? I hope it went well!" + (show)
@bluebonnet242

How did your reclast infusion go? I hope it went well!

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Low fever for 5 days, one episode of muscle spasm. Doing fine thanks!

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1 reply
bluebonnet242 | @bluebonnet242 | Jun 23 9:29pm
In reply to @windyshores "Low fever for 5 days, one episode of muscle spasm. Doing fine thanks!" + (show)
@windyshores

Low fever for 5 days, one episode of muscle spasm. Doing fine thanks!

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I’m glad it was tolerable for you. You always have the best attitude!

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zygote | @zygote | Jun 24 2:55pm
In reply to @artscaping "Good evening @alknapp and welcome to Connect. You have started a new discussion about what might..." + (show)
@artscaping

Good evening @alknapp and welcome to Connect. You have started a new discussion about what might be the best follow-up to Tymlos. I am glad to see that @windyshores has jumped right in to help you. And now I will try to help you by relaying my positive post-Tymlos experience.

After two successful years with Tymlos, my endocrinologist told me that the only option for me upon completion of Tymlos was Prolia. I didn't know enough at the time to dig in and do my own research. So I had twoProlia injections in the first year. After the first injection, I began to struggle with jaw pain. I kept a calendar that tracked the pain level and the number of days it lasted. At the same time, I started doing some research right here on Connect. Fortunately, my PCP recognized my struggle with Prolia and helped me secure a consultation with Dr. Wermers, an Endocrinologist at the Mayo Clinic.

The solution was to begin a weekly tablet of Alendronate (Fosamax) on the day that I was scheduled for my next injection of Prolia. This decision reduced the half-life amount of medication that was in my body. Some of us just don't have the ability to handle injections that last 6 months.

Suffice it to say, I will have completed 2 years of Alendronate this summer without any side effects. Then it will be time for a Dexa scan and I will know how well this medication maintained the bone that Tymlos built for me as well as the rest of the bone in my body.

Good luck with your decision. Please know that I am here for you.

May you be safe, protected, and free from inner and outer harm.
Chris

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Chris, I just started taking tymlos (10 days) and my heart is still racing. Per the tymlos site, the side effects will stop after the body gets used to it. I'm hoping you can tell me if this did happen to you,do you remember how long it took for your body to get used to tymlos?
Thank you

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2 replies
windyshores | @windyshores | Jun 24 3:31pm
In reply to @zygote "Chris, I just started taking tymlos (10 days) and my heart is still racing. Per the..." + (show)
@zygote

Chris, I just started taking tymlos (10 days) and my heart is still racing. Per the tymlos site, the side effects will stop after the body gets used to it. I'm hoping you can tell me if this did happen to you,do you remember how long it took for your body to get used to tymlos?
Thank you

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@zygote maybe try going down to a half dose ( 4 clicks of the pen) and then work up. I even went down to 1/4 dose (2 clicks) and worked up to 7 clicks. I was never really able to tolerate the full 8 clicks but had excellent gains. Ramping up from a lower dose lets the body get used to it without so much suffering !

This means using the pen for more than 30 days, potentially, so keep it in the fridge...

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1 reply
Mentor
Chris Trout, Volunteer Mentor | @artscaping | Jun 24 8:11pm
In reply to @zygote "Chris, I just started taking tymlos (10 days) and my heart is still racing. Per the..." + (show)
@zygote

Chris, I just started taking tymlos (10 days) and my heart is still racing. Per the tymlos site, the side effects will stop after the body gets used to it. I'm hoping you can tell me if this did happen to you,do you remember how long it took for your body to get used to tymlos?
Thank you

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Good evening, Zygote. I just reviewed your comment about Tymlos. I was actually a bit surprised by your comment about the side-to-side effects. This did not appear when I began my association with Tymlos three years ago. I may have had some minimal discomfort, but no pain.

I had started on Boniva and that was the wrong choice. After two months of tracking my levels of discomfort, my PCP and Endocrinologist suggested Tymlos. That turned out to be the right choice for me.

Good luck and good choices. Let me know how it works now.
Chris

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1 reply
zygote | @zygote | Jun 24 8:13pm
In reply to @windyshores "@zygote maybe try going down to a half dose ( 4 clicks of the pen) and..." + (show)
@windyshores

@zygote maybe try going down to a half dose ( 4 clicks of the pen) and then work up. I even went down to 1/4 dose (2 clicks) and worked up to 7 clicks. I was never really able to tolerate the full 8 clicks but had excellent gains. Ramping up from a lower dose lets the body get used to it without so much suffering !

This means using the pen for more than 30 days, potentially, so keep it in the fridge...

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Perfect! I will try tonight at 4 clicks .

REPLY
zygote | @zygote | Jun 24 8:14pm
In reply to @artscaping "Good evening, Zygote. I just reviewed your comment about Tymlos. I was actually a bit surprised..." + (show)
@artscaping

Good evening, Zygote. I just reviewed your comment about Tymlos. I was actually a bit surprised by your comment about the side-to-side effects. This did not appear when I began my association with Tymlos three years ago. I may have had some minimal discomfort, but no pain.

I had started on Boniva and that was the wrong choice. After two months of tracking my levels of discomfort, my PCP and Endocrinologist suggested Tymlos. That turned out to be the right choice for me.

Good luck and good choices. Let me know how it works now.
Chris

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I'm so happyI found this site. Thank you for responding.

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