@becsbuddy

I am happy to add to the information about treating Clippers with rituximab that was contained in the article "Effective treatment of CLIPPERS with long-term use of rituximab". I emailed the author of the article, Dr. Veronica Cipriani of UChicago Medicine, to ask her whether the patient she described in that 2018 article was still on rituximab today. Dr. Cipriani very graciously responded as follows: "I'm glad you reached out! I am happy to say that the patient from that case report is still on rituximab and doing very well. We were eventually able to take her from every 4 month rituximab to every 6 month, and recently we made the move to dosing every 9 months. Although CLIPPERS is often very responsive to steroids, we usually need an exit strategy because of all the long term complications of steroid use." So this patient of hers has been continuously on rituximab for 11 years! This is very positive news to me, since my neurologist is contemplating moving me from steroids to rituximab.

Dr. Cipriani also shared some information about CLIPPERS patients positive for MOG antibiodies: "I have another patient with a CLIPPERS presentation who is on IVIg and doing well on that. This is because he tested positive for MOG antibodies. I didn't know this when we wrote that case report, but there have been quite a few cases with positive MOG antibodies. Per the Mayo clinic, MOG is best treated with IVIg, so that is why I chose IVIg for that patient. This was written by some colleagues of mine: https://www.sciencedirect.com/science/article/abs/pii/S2211034821001413".