It is not the last. My husband was on it for 7 months before it quit working. Now he has been on fruquintinib for 5 months and it is keeping the tumors Stable So will continue. He sleeps 14 hours a day and his eyes burn and water. Dr said there are other drugs available but wants to keep them for when we need them. Colon cancer in both lungs. Hasn’t spread to any other organs which is huge.