@rjd the first half of Evenity is bone building and the second half, roughly, is anti-resorptive. It works very differently from other medications. It inhibits sclerostin. People born with low sclerostin may have very positive DEXA's and very dense bones (too dense). So researchers got the idea it might help osteoporosis and studies were done.

All the anti-resorptives work via different mechanisms. That's why Prolia has a rebound problem while bisphosphonates are used to deal with rebound.

The language about "coating bones" is from Keith MCormick's book "Great Bones," where he basically says Fosamax and other orals give spottier coverage, so to speak, in terms of protecting against rebound. But orals are fine if Prolia is taken for a year or a year and a half, he wrote.