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Arrhythmia and Prep for Colonoscopy
Heart Rhythm Conditions | Last Active: Jul 10 12:43pm | Replies (15)Comment receiving replies
The elimination half-life of Apixaban is approximately 12 hours (8-15 hour range). The full clearance is approximately 5.5 times that, or 3.5 days, during which time excessive bleeding is likely. I’ve stopped it 5 days in advance of prostate surgery and I still bled profusely.
The bigger issue is stopping the bleeding once it occurs as the reversal agents for Eliquis aren’t readily available.
Replies to "The elimination half-life of Apixaban is approximately 12 hours (8-15 hour range). The full clearance is..."
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Prostate surgery is a very bloody surgery. You blame eliquis for for bleeding profusely? I was diagnosed with PCa 23 years ago and have known many who bleed profusely.
From the article you link they recommend 48 hours for high risk surgery.
"The elimination half-life is about 12 hours (8 to 15 hours). Before a patient undergoes elective surgery or an invasive procedure, the drug should be held for 48 hours if the procedure is a moderate-high risk with clinically significant bleeding".
You say "The bigger issue is stopping the bleeding once it occurs as the reversal agents for Eliquis aren’t readily available."
If you had that kind of bleeding I assume you were in a hospital which is the only facilities to have it in stock.
"Andexanet alfa is a recombinant modified factor Xa protein approved by the FDA in May 2018 to reverse apixaban and rivaroxaban in patients with life-threatening or uncontrolled bleeding".