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Arrhythmia and Prep for Colonoscopy
Heart Rhythm Conditions | Last Active: Jul 10 12:43pm | Replies (15)Comment receiving replies
Eliquis has a clearance half-life of about 6 hours, the apparent half-life during repeat dosing is about 12 hours, which allows twice-daily dosing to provide effective anticoagulation, but it also means that when the drug is stopped for surgery, anticoagulation persists for at least a day. So why do docs for for 3 days or longer?
Replies to "Eliquis has a clearance half-life of about 6 hours, the apparent half-life during repeat dosing is..."
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The elimination half-life of Apixaban is approximately 12 hours (8-15 hour range). The full clearance is approximately 5.5 times that, or 3.5 days, during which time excessive bleeding is likely. I’ve stopped it 5 days in advance of prostate surgery and I still bled profusely.
The bigger issue is stopping the bleeding once it occurs as the reversal agents for Eliquis aren’t readily available.
Apixaban - https://www.ncbi.nlm.nih.gov/books/NBK507910/