Venclexta is a very effective therapy. I’ve been on it for many months along with infusions of Obinutuzumab and, yes, it works for me too. My only side-effects are daily nausea about 2 hours after taking Venclexta for which a take Compazine. It also severely suppressed my Lymphocytes and Neutrophils levels to point where I will need medication to boost those levels if they drop any further.

Realize there is no cure for CLL, and Venclexta is typically prescribed for about a year. The goal is deep remission and minimal residual disease. My thought would be to go off of it after a year and be monitored regularly for relapse. If it relapses, then go back on it or try whatever the latest first line therapy is. There seems to be new treatment discoveries on a regular basis.