Nonsteroidal anti-inflammatory drugs (NSAIDs) can inhibit platelet function and aggregation, which can increase bleeding times. NSAIDs do this by blocking the formation of thromboxane A2, a platelet-activating eicosanoid, by inhibiting platelet cyclooxygenase (COX). Aspirin irreversibly acetylates COX, while nonaspirin NSAIDs reversibly block it. So the small amount of aspirin to keep the platelets from being sticky and Tylenol if you have pain. Ibuprofen can cause bleeding problems. Also, tell your hematologist ALL medicines and supplements you are taking...your pharmacist can tell you about adverse reactions to medicine combinations, but your specialist needs to know everything, as well.