Mdd treatment

@elke1211 First of all, welcome to Mayo Clinic Connect. It really sounds like you have been trying so many different remedies. Is there any one or group that seems to have worked better than others? How long have you been living with major depressive disorder [MDD]? Sometimes it seems a combination works the best, rather than one thing in particular. Finding the "just right for me" combination can take a lot of patience, trial-and-error, and awareness. This may all be what you've heard before, but it bears repeating.

Starting from the beginning again, my suggestion is a complete physical, to rule out any organic causes or situations. Then move forward with tracking down how to work with your MDD. Diligent note-taking, journaling everyday or so, to get things out of your mind and onto paper, may present a pattern to you to see what triggers are, and give you something to focus on to solve. Does that sound doable?
Ginger

Hey there, I don’t have any suggestions, but I saw your post and wanted to say hi and offer you support in your search. Health issues can be devastating and frightening. I try to keep reminding myself that there is always hope if I keep trying. I’ve been struggling lately, and sometimes I’m weary of it, but I try to just do my best and try again tomorrow. I hope you can find something that helps. This site helps give me support.

I have done many of these interventions in tandem. I continue to retry things. I have been struggling 30 years. I’ll continue to try and journal. Just had a physical again last month and a thyroid ultrasound. So far groups have not been helpful since my teen years. I had hope then. I thought life could be better. I work in psychology, so I feel like I should be able to figure out new interventions. I just continue to try.

Have you tried Spravato? It has made a huge positive impact on my life.

My psych nurse practitioner did some things outside the norm. He had me take more than the maximum dose of Pristiq and added a mood stabilizer (Lamictal) that had recently been approved for MDD. In addition, I take Bupropion. I encourage you to keep trying! For me, it's been more than 50 years and I'm finally starting to feel better!

@elke1211 Sometimes we find ourselves trying different combinations, and wondering how long that trial is before we consider it's not the best thing for us. Having worked with so many different resources, it looks like there are numerous combinations for you to try.

For myself, sometimes I just need to be satisfied with doing my best, and consider it to be "good enough" for that moment. Yes, continue to try, please!
Ginger

Your story sounds like mine. I was long ago triaged into the “nothing to do keep comfortable” category. But something happened recently,

I insisted that my providers help me get off the long list of medications I was on. The first attempt ended with me in the hospital after I discontinued my meds to fast,

This next attempt is going better, though it is extremely painful. As the meds have decreased and the fog is clearing I have, with my providers help, been able to get to the core of the trauma that caused my depression to begin with,

It hurts like hell, but I at least know why I am suffering. With that has come some hope that I may one day come out of my hell and have a life.

I am sixty and I have been fighting this all of my life. Giving into the grief and letting it consume me for as long as I can, seems to be slowly healing me.

I don’t know if I will survive this, but I was dead anyway. I have a little bit of hope.

May you find some too.

Yes. I wish it had impacted me. Thanks for suggestion

Just wanted to check in and see how you are doing? I know this post is back from June but thought maybe you found something that works. I have suffered mdd for 25 years. Please let me know if you ever find something that helps

What is Spravato please?