I have PCV with Jack 2. I struggle with itching and slight headaches and ear aches. I started out with phlebotomies, then went to Hydroxyurea. That worked for a while until my platelets dropped. Now I’m on just baby aspirin. What I find with this disease is that it never stays the same, you need to be willing to do adjustments bloodwork calls for it. It’s like a roller coaster, but being active and have a good good mindset Really is the best medicine . Make sure you do research. Keep yourself informed and ask your oncologist. A lot of questions.