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Prolia and its side effects.

Osteoporosis & Bone Health | Last Active: Aug 20 10:39pm | Replies (69)

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@windyshores

@gently I wonder if, after dealing with rebound with Reclast or Fosamax, it is possible to get on a bone builder. Evenity is so new but maybe that is possible. I don't know if doctors even know.

My friend's doctor put her on Tymlos after Prolia. Leder and McCormick both say this sequence is not effective. What is the answer for those on Prolia who want to get off, beyond addressing rebound?

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Replies to "@gently I wonder if, after dealing with rebound with Reclast or Fosamax, it is possible to..."

@neverretire just want to add that Dr. Ben Leder in his YouTube video "Combinations and Sequencing Approaches to Osteoporosis" DOES have some good things to say about Prolia's effectiveness in increasing bone density. Dr, Keith McCormick ("Great Bones" page 546) does as well. The drawback, as both say, is the rebound if you need to get off. McCormick suggests using bone markers to time the transition to Reclast. If you could tolerate Prolia this might be the best option at this point but since you cannot tolerate Prolia, an expert endocrinologist can best guide you as to what to do.

The trouble with Prolia is the "resevoir" of preosteoclasts. You need the strongest medication to stop them. Zoledronate has the best mechanisms.
There is evidence that teriparatide therapy is more effective with Prolia. The HD Data trial evidenced that Prolia is able to "fully" inhibit the increased osteclast activity of Forteo It's possible to begin Tymlos or Forteo before the six months of Prolia is exhausted, You'd still need the antiosteoclast-antiresorptive at the end of six months. Would you want to stop the pth with the initiation of bisphosphonates. Maybe not.
I'm not happy with the idea of taking two of these pharmaceuticals concomitantly. Too many averse effects with just one.