← Return to Prolia and its side effects.
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Replies to "@gently I wonder if, after dealing with rebound with Reclast or Fosamax, it is possible to..."
The trouble with Prolia is the "resevoir" of preosteoclasts. You need the strongest medication to stop them. Zoledronate has the best mechanisms.
There is evidence that teriparatide therapy is more effective with Prolia. The HD Data trial evidenced that Prolia is able to "fully" inhibit the increased osteclast activity of Forteo It's possible to begin Tymlos or Forteo before the six months of Prolia is exhausted, You'd still need the antiosteoclast-antiresorptive at the end of six months. Would you want to stop the pth with the initiation of bisphosphonates. Maybe not.
I'm not happy with the idea of taking two of these pharmaceuticals concomitantly. Too many averse effects with just one.
@neverretire just want to add that Dr. Ben Leder in his YouTube video "Combinations and Sequencing Approaches to Osteoporosis" DOES have some good things to say about Prolia's effectiveness in increasing bone density. Dr, Keith McCormick ("Great Bones" page 546) does as well. The drawback, as both say, is the rebound if you need to get off. McCormick suggests using bone markers to time the transition to Reclast. If you could tolerate Prolia this might be the best option at this point but since you cannot tolerate Prolia, an expert endocrinologist can best guide you as to what to do.