For several years, I have used both 3% or 3.5% saline solutions in my Innospire Go nebulizer and I have not had any issues. After each use, I always rinse with warm water, let the nebulizer run for about a minute with the warm water in the basin then, after I dump the water I let the nebulizer run until I get the beep that indicates that it is empty. I then clean the solution basin and mouthpiece with a small alcohol wipe (about a 1" square likely used by diabetics).