I agree if only there was a cure I would never take that high of a dose of 2400 mg a day that can definitely have side effects I find that taking two 300 mg at night is the best thing to calms my feet from the burning and tingling it helps me to sleep through the night I also take a very low dose of Cymbalta/ Duloxetine of 30 mg in the morning my doctor says the two work good together I have been doing this for several years it does not take everything away but it sure does help get a good night's sleep