@catartist Yes, I can't get off prednisone. I just had a relapse and am now back up to 20mg daily. It is hard. It intensifies my tingling/pain, but also helps the pain. My muscles in my legs and glutes seem to be the first of the muscle wasting. My strength has gone too. Rituxan gave me really, really bad mood swings. It was to the point my poor husband would come home from work and take a few minutes in the truck before coming into the house. My dr took me off it right away. I never tried methotrexate. What is that used for?