One more question. How do I start a thread about Nourianz. This drug in combination with DOPA appeared to reset my husbands disease. He regained spatial abilities, better thinking and memory, functionality. The drug appears to have minimal effect in most people - a minor help during the off-period. I wonder if any others responded as my husband did. Our neurologists has asked colleagues and I asked the CVS Specialty Pharmacists but responses were it is a new drug and responses are the off-time improvement not the major changes.