I was on Mirapex for 11 years. After 11 years I changed from my first neurologist PA to Mayo. They immediately stopped the Mirapex and started me on Sinimet. I get very nauseated from Sinimet so switched to Rytary about 2 months ago. I feel like I have less off time, less nausea and feel less fatigued. I still have more nausea than I would like. I take Lodosyn and Domperidone with each dose of Rytary to help with the nausea. Does anyone have any suggestions for nausea. I am taking 3 capsules 3 times a day of the Rytary. I am seeing my neurologist at Mayo today and am hoping to either increase my dose to 4 capsule 3 times a day or 3 capsules 4 times a day. I live in Minnesota and there is some type of community program in Minneapolis that makes it affordable. I pay $15/month. Other wise it was over $1000 a month. I have to call this center when I have 1 week supply left and then they over night send it to me. Mayo set this up for me.