Hi, @sisle. I am happy to welcome you to Mayo Connect. When I was first diagnosed with PSC, I did not have any outward symptoms, but as the disease progressed, I did have serious itching, along with other symptoms. I received a transplant (liver and kidney) in 2009 as a result of my PSC progression to liver failure and kidney failure.

I'm one of the patients who used a lot anti itch lotions. I was not familiar with Rifampin, so I did look it up and found this information on the website for PSC Partners Seeking a Cure .
"Rifampin is an antibiotic mostly used for the treatment of tuberculosis...it has also been shown to help relieve pruritus (itching). ..may cause changes in other medications you are taking....Make sure your doctor is aware of all other medications you are taking... in order to avoid any possible conflicts..."
I would like to share the link for those who might not be familiar with it.
- PSC Partners Seeking a Cure
pscpartners.org/

@sisle. Thanks for sharing! How long have you been taking Rifampin? Do you have PSC that is causing your itching?