HU has not lowered my RGB to below-normal levels. (I am 70 yo F with CALR mutation, on HU for 6 yrs, 500 mg per day plus 1 extra on M/W/F, platelets in 400s.) If your platelets stay below 400, you might ask doc if you can reduce HU some more. Getting the right dose may take a year or two. Everything with ET goes at a snail's pace. Cultivate patience.

Most hemos seem to want to find the lowest effective dose that will keep platelets in the zone that will not increase stroke risk. They increasingly take your overall stroke risks into consideration (mutation type, age, previous clot history, food/exercise habits, family stroke history, etc) when dosing.

Drinking at least 68 oz water per day + Miralax once a week helps me with the constipation. I also take a probiotic once a day. I thought that was just New Age hooey until the oncologist suggested it, and it has made a difference. But, as always, mention to your doc before experimenting.

Have had ET for 15 years, and I feel pretty good. Good luck with the BMB. Mine went just fine and was over in 10 minutes.