As a P,.S., the Tamoxifen dosage was increased by my Texas oncologist on June 23 from the 10 mg. I said I would take to 20 mg. daily. I went from 40 mg. a week to 140 mg. a week (the normal dosage at 20 mg. daily), That was when things went down the tubes for me. Personally, I don't understand how or why there isn't titration of dosages to take into account a person's age and weight, etc. "One size fits all" does not seem right and yet the reason I was told to "step it up" was that "We don't have any clinical evidence that the amount you are taking now (10 mg. every other day) will protect you. We only have evidence for 20 mg. a day." He pointed out to me that the Italian Women's Study involved women whose tumors had NOT broken through, whereas mine was invasive. I complied, because I like my Texas oncologist, and I understood what he was telling me, but I also understand that "life is short and then you die" and I want to have as pleasant a decade or two as I can during the 15 years or so that I may have left. My mom was a 4-shots-a-day diabetic who lived to be 96. I hope to come close to being as active and sound of mind as she was right up until 4 months before her death in May of 2002.