vinny59 (@vinny59) One variable that you haven't mentioned is your age since if you are 70+ I would recommend radiation but any younger I would go with removal. The reason is that the long-term outcomes are better with removal. I was 73 when I received SBRT Proton treatment for my cancer in 9/2020 at Mayo Rochester. My PSA was 11+ with a 4+3 Gleason score. After radiation my PSA has remained at < 0.1 However, upon further thought, I would go against my suggestion due to your other multiple cancers; get it removed.