Adapting to meds isn’t easy so I hope your mom will start to adjust to her higher dosage soon. Feeling queasy is no fun. I’m sure you’ll both be eager to see what the next labs show! Fingers crossed that the HU starts lowering those platelets to a normal level. As you can see, there are a number of members here who are taking HU and are concerned about your mom. So please let us know how she’s doing.