Wow that is an extremely high amount to start on but I can only assume it was to get her platelets out of that very high danger zone and avoid throwing a clot. Pretty sure she will go to one a day and monitor for about two months. I began with platelets just over 800 and 500 mg daily. After one month went down to 200. Went to 5X a week and after about 7 months got the dosage straight on 3X a week. I’m holding steady for almost a year on this dosage. My platelets are about 480 and my oncologist is fine as long as I stay under 600. High doses gave me some nasty side effects such as hair loss, swollen gums, extreme sensitivity to sun and small brown spots on my skin. I’m hoping I can hold steady on this dosage. I am JAK2 positive and have Polycythemia Vera, diagnosed 1/23.