My dad's cancer returned and now it’s stage 4 metastatic cancer

Posted by ihatecancer @ihatecancer, May 3 7:49am

Hello,

6 years ago my dad was diagnosed with prostate cancer and had prostate surgery. He seemed to have an aggressive form and had to do radiation and hormone therapy after surgery for some time.

Yesterday we were informed that the cancer has returned in his spine, meaning it’s spread to the bone. The doctors located a tiny spec of the cancer and have told my dad to undergo radiation for a few days and then start hormone therapy.

In the past my dad hated the side effects from the hormone therapy and from my understanding now that the cancer has metastasized he will be on hormone therapy for the rest of his life.

Has anyone here experienced a similar situation and can share your experience. Is the quality of life still okay with hormone therapy?

I’m so sad for him as he finally decided to retire at the end of the month, but now has this situation to deal with. I’d appreciate any insights on being on hormone therapy for life and if there are any other major issues that can happen due to the medications.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

@northoftheborder

That's exactly my situation — I was diagnosed with oligometastatic prostate cancer to my spine at age 56, 2½ years ago, and am on ADT indefinitely — and I feel that I'm living a pretty-great life.

The side-effects can be occasionally annoying, but the extra years are priceless.

(In my case, though, it wasn't just a speck — it was a big lesion that compressed my spinal cord and left me paraplegic for many months, so there was no doubt about the scan.)

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I’m sorry you are also battling this disease but very happy to hear that you are living a great life. Your story and all the other stories are so very helpful to hear about.

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@grandpun

Hello 'IHATECANCER',
sounds like you and your dad are doing the right and best things. Best of luck throughout the ordeals.
I had prostatectomy 01/2022 but had a spot on a rib so two years of Lupron. Luckily, I got my last shot of Lupron 01/2024, two years worth. My PSA has been and is - and hope it stays - negligible. Hooray!!!
But now I'm waiting for the lousy hot flashes to subside. My oncologist says Lupron doesn't have a "Half-life" so there's no fixed time for the side effects will subside. I'm trying to wait patiently (or not).
And he said it takes time and the older you are the longer it tends to take. I'm 77 so your dad has a 10-year advantage on me; I hope he can follow the same course of "just" a couple years of shots.
Also, I started taking paroxetine a ways back, and still do. It helps reduce the flashes intensity and lower their frequency.
And encourage him to keep active! Muscle loss is another of (my) side effects. So fitness class, lawn, volunteering, and spoiling grandkids (5, 8, 19, and 21) are priorities for me.
Good luck and my/our prayers. Tell him we're all brothers in this constant fight and join us in praising the Good Lord for the skills and tech our doctors can provide.
And you are the "good kid" to stick by him and help him in this battle.

(And my GrandDaughter's wedding? - the young one is now only 5. Great idea so I'm going for it!!!)
Blessings,
Bob

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Thank you for sharing and sending you all the positive thoughts that your PSA stays negligible! 🙏🏽

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@web265

Hey @ihatecancer
I'm fairly certain my father was simply on Lupron later in life, I'm not aware of any pills. Now the standard of care is often what is called "doublet" or even "triplet" therapies where two to three meds are often taken to get a better result.

The orgovyx is what I take daily, 120 mg pills. The belief is that this may be better in my situation because it delivers a more even dose everyday. It's fairly new so they are still learning about it. As I understand it, patients are also believed to recover testosterone levels faster when they stop taking it. Starting with my next blood test (a few weeks) and after I stop the drug, we'll start monitoring testosterone levels to see how / if it returns.

If your Dad is 67 and not working out, it might be better to start with walking and maybe swimming if you have access to a pool.....

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Thank you for the information. Your stories are so very helpful. Sending you nothing but positive thoughts that your blood results are good!

My dad starts radiation tomorrow for three days (MWF). His doctor also asked him to start taking Bicalutamide two days ago. He has been instructed to take this for one week before Lupron and one week after. Have you heard of this drug and process before?

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@kujhawk1978

I can't really add anything different than what others have said.

It is likely with spread to the spine that your father may be in continuous ADT.

With modern PSMA imaging and the advances in radiation planning and delivery, SBRT may be able to treat his spinal mets.

Likely his medical team will want him on ADT and an ARI. For the ADT, lots of choices, Orgovyx is one. There are still the side effects, hot flashes, muscle and joint stiffness, fatigue, genitalia shrinkage, loss of libido...though those on this forum and others say they are "less severe." I just completed 12 months, combined with SBRT to the single PLN identified in the PLarify scan, my sensing is yes, less severe, but that's a qualitative, not quantitative judgement. Hot flashes suck.

Still, while on treatment I changed nothing, most days went to the gym, took vacations to Oregon, the Great Sand Hill Crane Migration in Nebraska, went skiing with friends in Colorado, celebrated birthdays, anniversaries, rode with my sister in the Garmin Unbound 50, a 50+ mile gravel bike ride in the Flint Hills of Kansas near Emporia,

My medical team can and does a lot for me, what they cannot do which are useful in mitigating the side effects of treatment:

Exercise
Diet
Managing Stress.

Kevin

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Thank you Kevin for sharing your story. I’m happy to hear you still continue to live your life and do all the things you love. I do believe that sometimes it’s mind over matter and you have to that positive mindset.

Also, thank you for sharing your chart. I noticed a note on there mentioning afib. Do you have that as a result of the medications?

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@ihatecancer

Thank you Kevin for sharing your story. I’m happy to hear you still continue to live your life and do all the things you love. I do believe that sometimes it’s mind over matter and you have to that positive mindset.

Also, thank you for sharing your chart. I noticed a note on there mentioning afib. Do you have that as a result of the medications?

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I first noticed it after a dinner date with my wife where we shared a bottle of wine.

My cardiologist said I needed to stop drinking...or go on medication...

He had no cause and effect correlation but I said maybe it's the ADT...I had no scientific cause and effect either but a strong intuitive correlation.

I said I would watch my drinking, usually 7-10 a week.

He put me on medication which didn't work, kept getting breakthrough episodes.

He tried cardioversion once when my heart wouldn't come out of AFib by itself. My wife was not enamored with the idea of stopping my heart....

Finally when he said the only medication left required three days in the hospital for monitoring because if the side effects, we said do the ablation.

Problem solved!

So, yes, I do think ADT was a causation. Can I prove it, no!

It is why I say you should have a cardiologist on your team!

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@ihatecancer

Thank you for the information. Your stories are so very helpful. Sending you nothing but positive thoughts that your blood results are good!

My dad starts radiation tomorrow for three days (MWF). His doctor also asked him to start taking Bicalutamide two days ago. He has been instructed to take this for one week before Lupron and one week after. Have you heard of this drug and process before?

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I've heard of it but haven't taken it or looked into it. It's mentioned on this forum, perhaps you can find more info by searching here.

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@ihatecancer

Thank you for the information. Your stories are so very helpful. Sending you nothing but positive thoughts that your blood results are good!

My dad starts radiation tomorrow for three days (MWF). His doctor also asked him to start taking Bicalutamide two days ago. He has been instructed to take this for one week before Lupron and one week after. Have you heard of this drug and process before?

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These drugs are standard of Care I was on Zolodex and still am for 7 years just like Lupron

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how old is your dad? Do you know what his Gleason score was? Whats his PSA at now? One spot was determined by a PSA Pet scan ? Ask Dr about 5 months on ADT then 5-6 months off . Efficacy research is promising . Hope to hear back . James - Vanc Island .

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@melcanada

These drugs are standard of Care I was on Zolodex and still am for 7 years just like Lupron

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How long does your doctor say you can be on zolodex . Can you go 6 months on 6 months off ?

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Since your dad’s prostate cancer metastasis is only to bone, have they recommended Xofigo (Radium-223)?
Here is information: https://www.bayer.com/en/news-stories/radium-223-prostate-cancer

Here is a technical description: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593411/

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