The meds will work but takes a while to get the dosage correct. My platelets were over 700. I started with seven days a week and after two months they dropped down to under 200. Went to 5X a week and now at 3X a week for a year and am steady just under 500 which is acceptable. I hope to stay on this low dose. Higher doses caused my teeth to hurt, swollen gums, extreme sensitivity to sun and hair loss. Good luck! I’m JAK2 positive and have Polycythemia Vera diagnosed Jan 2023.

I have been on meds for 12 years. My only risk factor for heart attack/stroke is that I am I over 65. I take 1 pill of hydrea every day and an extra on Monday Wednesday and Friday. My counts are still I over 700. I refuse to take anymore. I can function okay but not at the level I was used to and my hair is thinning.
I had a second opinion and the hematologist said that as long as the numbers were under 1 million and no additional risk factors that I should be okay. I guess every doc has their own way of interpreting the studies. My guide is - how do I feel. I refuse to sit on the couch all day and worry about it.