If you would provide your age, your PSA history, and any MRI data, people can make more informed comments.
Generally Decipher is not indicated for 3+3
Thanks.

Rice, decipher will give you useful information. With no change if the 3+4 if the sample is large enough this time, I'd ask for it. Not sure if your provider is dismissive of Decipher of decipher for you at this point.
You might want to look at focal therapy. It good to hear of someone catching prostate cancer early enough not to treat the entire prostate. Best wishes.

ok I am 72, My PSA has been between 4 and 8. My PSA has always been all over the place. I have had 2 MRIs, they were used for the targeted biopsy. I have had 2 Pet scans nothing is outside of the prostate. Because I had 3+4 in less then 2% 0f one core and 3+3 in 25% of another core so I am assuming that I am a overall 7 . My Doc says I am stable. My radiologist told me that if my latest biopsy did not change he could do radiation in 5 treatments and no HT. But because I have BPH he would want me to get a HELOP. That Is why I am wondering about doing the decipher test so I can make up my mind to continue active surveillance or go with Radation option. thanks

@rice My MRI/Fusion biopsies showed 3+4=7. This indicated standard treatment of radiation and hormone as is classified at least at Mayo Jacksonville as intermediate.

Mayo R/O suggested Decipher test and it was done. It dose not require another biopsy but they use the already taken tissue. My Decipher test came back LOW RISK which removed the need for hormone treatments.

So if you asked if Dechiper test is worth in or do I think you should have it, YES. Both Mayo and UFHPTI both recommended it and went by their findings to developed a treatment plan. I would also suggest you research Decipher test to gain your own knowledge of this more specific risk diagnosis I would also research and consider asking your urologist and or R/O about a PSMA and bone scan. They too can show if spread outside the prostrate.

If you have a biopsie at 3+4 it means you should be looking at second opinions, more tests, etc. A 3+3=6 ususally means watching. Just be aware that when doing biopsies it is NOT all of prostrate and areas even microscopic that have cancer can be missed. It is why my R/O at UFHPTI did radiation on all my prostrate to ensure all was treated and did not miss an area they biopsies did not find.
Good luck,

Because of my personal history I would recommend the decipher test. My original biopsy in 2020 came back 3 + 3 low risk. I asked for a decipher test and my urologist said that it wasn’t worth it for low risk low Gleason score disease. He suggested focal therapy so I had one side of the prostate treated with LDR brachytherapy. The only problem was that the biopsy missed significant high risk disease and 3 years later cancer returned with a vengeance. I now have Stage 3 metastatic PCa and genetic testing on my prostate after RP confirms that I never had low risk disease as Gleason 6 doesn’t morph into Gleason 9. Had the decipher test been performed it likely would have shown mutations that would have at minimum initiated a repeat biopsy and reevaluation.

You have to be your own advocate. Hope things go well for you.

Rice, I'd be worried if my doctor didn't think much of the decipher test. But I forgot to mention that the decipher results report is about 28 pages long. But you have to ask for the "grid" Otherwise you'll receive a simple 3 pages about risk. It is probably better to call Decipher to ask for the full report. https://decipherbio.com/decipher-prostate/physicians/grid/

The Grid report is " For Research Use Only" and not necessarily used for diagnosis, staging or treatment.

Information from the grid let me know that the tumor was androgen active, glucose active by which and how much each gene was implicated. It will tell you how active your immune system is. A little further research can tell you which genetic mutations have proven susceptible to which chemotherapeutic agents. And could clue you in to which clinical trial might likely benefit you. It can tell you if metformin or statins would likely benefit you.
The decipher score "is determined solely by the genomic characteristics of the tumor" itemized on the Grid labled "Research Use Only."

toolbelt, where do you think Decipher finds the information to determine your score. Do you expect that your Decipher score is proven fact. The decipher score is the nugget dug out of their Grid.

Rice: I had the decipher test and it was used by all five of the radiation oncologists that I spoke with from either centers of excellence or with backgrounds from centers of excellence to make or change their diagnosis. I too, would question your doctor for not doing it. It is also a way to get another opinion which never hurts and will help you make a decision, in terms of the mode of treatment and aggressiveness level, as well as helping your doctors. All these doctors are making educated guesses.