I was put on Eliquis a year ago. I also have been on Plavix for about 4 years ago. When I started on Eliquis I broke out in a rash. I couldn’t find one doctor who thought the two were related. I asked to be put on Xarelto 6 months later. The rash continued but lessened. I think I am resolved that it will be with me for as long as I am on those two. Plavix caused no problems at all.