Evenity and side effects: What helps joint and muscle pain?

@drsuefowler Perhaps I've already mentioned this to you but just so others reading these threads discussing Evenity side effects don't get too depressed I'll repeat this - Evenity does not always or even often cause noticeable side effects. Even in sensitive people.
I've been severely food and chemically sensitive for over 40 years and I'm (knock on wood) having only the slightest side effects with Evenity. By slight I mean I get mildly stimulated from the injection and that lasts through the day of the shot. I get a slight pressure in my forehead which does not get bad enough to be called a headache. In contrast my eating the wrong food (and most all foods fit in the wrong food category for me) or smelling the wrong odor can wreck my day. Quite amazing to me how very very little trouble I'm having with Evenity.
But I am not discounting the experience of others who are having really unpleasant side effects, not at all - I just wanted to say that the odds for any given person even those sensitive types, may not be very high?
I do find it strange that all the osteoporosis meds seem to have pretty awful side effects for some while others have little to no side effects. Such a huge range of reactions to these drugs!
I wish it was more clear what percentage of us have the bad side effects to the different osteoporosis meds. And of course we need some means to predict who might or might not react badly.
Myself as I'm past shot 7 of Evenity, am most worried about the next med.

All - For what it’s worth, I’ve had the following prescribed to me since 2011 and all at “full strength” (meaning no partial doses): Several different oral bisphosphonates, Reclast infusions for five years (from 2011), Reclast again in the early 2020’s, nine months of Tymlos and now, Evenity (10 months in).

The oral bisphosphonates caused stomach issues which prompted my doc to prescribe Reclast. No issues with Reclast in either series. Although Reclast seemed to keep my bones “holding steady” it seems after my early ‘20’s infusions, my doc learned of drug holidays and halted the infusions. Tymlos caused so many issues for me that I finally told the doc I’d had enough. Enter Evenity and so far, so good.

Honestly, I’ve been preparing to ask the doc to prescribe Reclast post-Evenity because of no previous issues with it; at first he said that would be fine, but lately both he and his CRNP are dragging their feet and pushing Prolia . . . without telling me why. Also, with the posts here, I’m beginning to fear Reclast as well.

It has become evident that what works for one of us will not work for others. Don’t be afraid to challenge your doc about starting and/or stopping meds that they deem necessary, safe or helpful . . . If I had spoken up sooner about my desire to stop Tymlos, I could’ve likely saved thousands of dollars and countless time in docs offices, ER’s, etc. My rheumatologist was well aware of my symptoms, but never once considered that they could be caused by Tymlos because “those symptoms aren’t listed” on the manufacturer’s website; my quick call to Radius and they are now!

Thanks for listening as I drone on about my Tymlos issues, the med does seem to work for some, but I’m pretty pissed about how long it took my doc to react to such debilitating problems.

Wishing everyone great bones! Cheers!

It's possible Tymlos would have worked for you @beanieone, at a reduced dose or with a protocol for ramping up slowly to whatever you could tolerate.

@windyshores, Perhaps, but I’ll never know and I can’t worry about it because Evenity is working well for me. My DEXA scores improved greatly compared to my last one (2022 vs 2024) and I can’t honestly give sole credit to either med.

If I had thought about it, or had read your posts about ramping up the dosages beforehand, the outcome may have been different. This med is marketed as a “one dose fits all”, but there should be additional research done for those of us who are smaller in frame, body weight, and/or stature. I felt like I had been poisoned - within a few days to a week after stopping Tymlos, the side effects had subsided. I’m glad you were able to work through any problems you had with Tymlos. We all need to find what works for us. Cheers!

All - For what it’s worth, I’ve had the following prescribed to me since 2011 and all at “full strength” (meaning no partial doses): Several different oral bisphosphonates, Reclast infusions for five years (from 2011), Reclast again in the early 2020’s, nine months of Tymlos and now, Evenity (10 months in).

The oral bisphosphonates caused stomach issues which prompted my doc to prescribe Reclast. No issues with Reclast in either series. Although Reclast seemed to keep my bones “holding steady” it seems after my early ‘20’s infusions, my doc learned of drug holidays and halted the infusions. Tymlos caused so many issues for me that I finally told the doc I’d had enough. Enter Evenity and so far, so good.

Honestly, I’ve been preparing to ask the doc to prescribe Reclast post-Evenity because of no previous issues with it; at first he said that would be fine, but lately both he and his CRNP are dragging their feet and pushing Prolia . . . without telling me why. Also, with the posts here, I’m beginning to fear Reclast as well.

It has become evident that what works for one of us will not work for others. Don’t be afraid to challenge your doc about starting and/or stopping meds that they deem necessary, safe or helpful . . . If I had spoken up sooner about my desire to stop Tymlos, I could’ve likely saved thousands of dollars and countless time in docs offices, ER’s, etc. My rheumatologist was well aware of my symptoms, but never once considered that they could be caused by Tymlos because “those symptoms aren’t listed” on the manufacturer’s website; my quick call to Radius and they are now!

Thanks for listening as I drone on about my Tymlos issues, the med does seem to work for some, but I’m pretty pissed about how long it took my doc to react to such debilitating problems.

Wishing everyone great bones! Cheers!

Beanieone, it is so helpful that we hear your experiences. The real world effect is the most valuable part of this site. And you give excellent advice about trusting your symptoms when they aren't listed on the manufacturer's website. Thanks

It's possible Tymlos would have worked for you @beanieone, at a reduced dose or with a protocol for ramping up slowly to whatever you could tolerate.

I have to start reclast after Evenity and do you have any tips I could use for wanting to start with smaller doses at first…if Reclast is given once a year…( is it?) then aren’t we pretty helpless to help ourselves all year?
Advice needed on how best to communicate and help ourselves…I was only given two choices Reclast & Prolia…not any discussion at all just choose.