Hi @catbuddy, in addition to the helpful post from @wooldridgec, I'm tagging fellow members like @foamhand @kjbushur @heal623 @healer74 @baxterlee77 who have experience with Zometa (zoledronic acid) and can share as well.

With respect to your radiation questions, you might check out these related discussions:
- Is SBRT with proton beam now a gold standard for prostate cancer?
https://connect.mayoclinic.org/discussion/sbrt-with-proton-beam/
- Can Proton Beam Therapy be used when prostate cancer has spread?
https://connect.mayoclinic.org/discussion/proton-beam-therapy/

More proton beam discussions: https://connect.mayoclinic.org/group/prostate-cancer/?search=Proton%20beam&index=discussions

- Anyone have stereotactic body radiation therapy (CyberKnife)?
https://connect.mayoclinic.org/discussion/cyberknife-procedure/

- Proton Therapy or Cyberknife without ADT for Gleason 8?
https://connect.mayoclinic.org/discussion/proton-therapy-or-cyberknife-without-adt-for-gleason-8/